How ACCRUFeR Works

ACCRUFeR^® (ferric maltol) is iron you’ll actually take

ACCRUFeR is uniquely formulated with a “maltol shield” that keeps iron protected as it passes through your stomach so it is ready for absorption in the small intestine. This can mean fewer gastrointestinal (GI) reactions like gas, diarrhea, and nausea.

Man smiling with arms crossed and overlay of ACCRUFeR with “maltol shield” inside stomach

ACCRUFeR’s unique “maltol shield” helps reduce the likelihood of GI side effects.

ACCRUFeR is unique because its iron is protected by a sugar-like substance called maltol. The maltol shields the iron from the stomach so it doesn’t break down earlier than it needs to. This leads to demonstrated absorption in the small intestine and limits the amount of “free” or unabsorbed iron in your body.

Keeping the iron protected from the stomach is key to preventing GI side effects.

When iron supplements break down in the stomach, the iron clumps together, making it hard for the body to absorb later.
Then, the unbound iron starts to interact with other molecules in the body, which can create highly reactive chemicals. These chemicals can cause damage and irritation in the gut, contributing to unpleasant gastrointestinal effects, like pain, constipation, diarrhea, or nausea.

Side Effects of Iron Supplements

ACCRUFeR in Action

how_accrufer_works_image_description — Tightly bound in the stomach and absorbed in the small intestine

The “maltol shield” protects iron from the stomach, remaining tightly bound to the iron as it passes through. The iron is absorbed in the small intestine, which limits free iron and lowers the risk of damage and irritation. Excess iron is excreted in the stool.

ACCRUFeR’s Unprecedented Tolerability

Intolerable side effects can be a barrier to staying on treatment. ACCRUFeR is different. In clinical studies, fewer than 5% of patients taking ACCRUFeR stopped taking it because of adverse reactions.*

*Out of 175 patients

Taking ACCRUFeR

Patients take a 30 mg gluten-free capsule twice a day. Because ACCRUFeR stays intact in the stomach, its iron is ready to be absorbed in the small intestine, so a low dose twice a day is enough to raise iron levels.

ACCRUFeR can be taken on its own. Stool softeners and supplements, like Vitamin C, are not needed to help ACCRUFeR work or to manage side effects.

How should I take ACCRUFeR?

Take ACCRUFeR exactly as your doctor tells you. Tell your doctor about any medical conditions and medicines that you currently take, including over-the-counter medications, vitamins, and herbal supplements.
Take ACCRUFeR twice a day on an empty stomach. This may be 1 hour before or 2 hours after a meal.
Swallow capsules whole. Do not open, break, or chew the capsules.

Please review the Product Information sheet for more information.

Benefits of ACCRUFeR

ACCRUFeR has a unique design that protects iron from your stomach, so it can be absorbed in the small intestine. This can mean fewer unwanted gastrointestinal side effects.

Our Clinical Studies

Review the results for patients in clinical studies.

IMPORTANT SAFETY INFORMATION

Do not take ACCRUFeR if you are allergic to ferric maltol or any of the ingredients in ACCRUFeR; have any illness that causes you to store too much iron in your body or if you have a problem with how your body uses iron; are receiving repeated blood transfusions.

Before you take ACCRUFeR, tell your doctor about all your medical conditions, including if you have inflammatory bowel disease (IBD); are pregnant or plan to become pregnant (it is not known if ACCRUFeR will harm your unborn baby; talk to your doctor if you are pregnant or plan to become pregnant); are breastfeeding or plan to breastfeed (it is not known if ACCRUFeR passes into your breast milk); talk to your doctor about the best way to feed your baby if you take ACCRUFeR.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ACCRUFeR and certain other medicines may interact, which could potentially cause serious side effects. Some medicines may need to be taken at least 4 hours before or 4 hours after you have taken ACCRUFeR. Ask your healthcare provider for a list of these medicines if you are not sure if you take one of these medicines.

Especially tell your healthcare provider if you take:

Dimercaprol

Other oral iron tablets or health supplements containing iron

Ask your healthcare provider if you are not sure if you take one of these medicines. Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ACCRUFeR?

ACCRUFeR may cause serious side effects including:

Increased risk of inflammatory bowel disease (IBD) flare. You should avoid taking ACCRUFeR if you have IBD and are experiencing a flare

Too much iron stored in your body (iron overload). Your healthcare provider should check the iron level in your blood before you start treatment with ACCRUFeR

Risk of overdose in children due to accidental swallowing. Accidental overdose of iron-containing products is a leading cause of death from poisoning in children under 6. Keep ACCRUFeR in a safe place and out of the reach of children

The most common side effects of ACCRUFeR include gas, diarrhea, constipation, discolored stools, stomach pain, nausea, vomiting, and stomach area discomfort or bloating. These are not all the possible side effects of ACCRUFeR. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.