How ACCRUFeR Works

ACCRUFeR^® (ferric maltol) is iron you’ll actually take

ACCRUFeR is uniquely formulated with a MALTOL SHIELD^TM that keeps iron protected as it passes through your stomach so it is ready for absorption in the small intestine. This can minimize the risk of gastrointestinal (GI) reactions like gas, diarrhea, and nausea.

Man smiling with arms crossed and overlay of ACCRUFeR with maltol shield TM inside stomach

ACCRUFeR’s MALTOL SHIELD^TM supports iron absorption and tolerability

The iron in ACCRUFeR is protected by a sugar-like substance called maltol. The maltol shields the iron from the stomach so it breaks down where it's needed in the small intestine. This leads to demonstrated absorption and limits the amount of “free” or unabsorbed iron in your body.

Protecting iron from the stomach is key to achieving absorption and minimizing the risk of GI side effects.

When traditional iron supplements break down in the stomach, the iron clumps together, making it hard for the body to absorb.
Unbound iron can lead to inflammation in the gut and disrupt the microbiome which contributes to GI side effects like pain, constipation, diarrhea, or nausea.

Side Effects of Iron Supplements

ACCRUFeR in action

Your body might be using only a fraction of the iron you take in from OTC supplements. See what sets ACCRUFeR apart:

ACCRUFeR’s Unprecedented Tolerability

Intolerable side effects can be a barrier to staying on treatment. ACCRUFeR is different. In clinical studies, fewer than 5% of patients taking ACCRUFeR stopped taking it because of adverse reactions.*

*Out of 175 patients

Taking ACCRUFeR

Patients take a 30 mg gluten-free capsule twice a day. Because ACCRUFeR stays intact in the stomach, its iron is ready to be absorbed in the small intestine, so a low dose twice a day is enough to raise iron levels.

ACCRUFeR can be taken on its own. Stool softeners and supplements, like Vitamin C, are not needed to help ACCRUFeR work or to manage side effects.

How should I take ACCRUFeR?

Take ACCRUFeR exactly as your doctor tells you. Tell your doctor about any medical conditions and medicines that you currently take, including over-the-counter medications, vitamins, and herbal supplements.
Take ACCRUFeR twice a day on an empty stomach 1 hour before or 2 hours after meals.
Swallow ACCRUFeR capsules whole. Do not open, break, or chew the capsules.

Please review the Product Information sheet for more information.

Benefits of ACCRUFeR

ACCRUFeR has a unique design that protects iron from your stomach, so it can be absorbed in the small intestine. This minimizes the risk of unwanted gastrointestinal side effects.

Our Clinical Studies

Review the results for patients in clinical studies.

IMPORTANT SAFETY INFORMATION

Do not take ACCRUFeR if you are allergic to ferric maltol or any of the ingredients in ACCRUFeR; have any illness that causes you to store too much iron in your body or if you have a problem with how your body uses iron; are receiving repeated blood transfusions.

Before you take ACCRUFeR, tell your doctor about all your medical conditions, including if you have inflammatory bowel disease (IBD); are pregnant or plan to become pregnant (it is not known if ACCRUFeR will harm your unborn baby; talk to your doctor if you are pregnant or plan to become pregnant); are breastfeeding or plan to breastfeed (it is not known if ACCRUFeR passes into your breast milk); talk to your doctor about the best way to feed your baby if you take ACCRUFeR.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ACCRUFeR and certain other medicines may interact, which could potentially cause serious side effects. You may need to take ACCRUFeR at least 4 hours before or 4 hours after you take certain medicines. Ask your healthcare provider for a list of these medicines if you are not sure if you take one of these medicines.

Especially tell your healthcare provider if you take:

Dimercaprol

Other oral iron tablets or health supplements containing iron

Ask your healthcare provider if you are not sure if you take one of these medicines. Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ACCRUFeR?

ACCRUFeR may cause serious side effects including:

Increased risk of inflammatory bowel disease (IBD) flare. You should avoid taking ACCRUFeR if you have IBD and are experiencing a flare.

Too much iron stored in your body (iron overload). Your healthcare provider should check the iron level in your blood before you start treatment with ACCRUFeR.

Risk of overdose in children due to accidental swallowing. Accidental overdose of iron-containing products is a leading cause of death from poisoning in children under 6. Keep ACCRUFeR in a safe place and out of the reach of children.

The most common side effects of ACCRUFeR include gas, diarrhea, constipation, discolored stools, stomach pain, nausea, vomiting, and stomach area discomfort or bloating. These are not all the possible side effects of ACCRUFeR. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.